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Back You are here: Home Health Health The problem with a colonoscopy

The problem with a colonoscopy

ColonoscopyThey may the gold standard for examining the bowel, but colonoscopies may be unduly dangerous, writes Dr John McDougall.

13 March 2011

Following the 2001 McDougall Adventure Trip down the Amazon with 58 fellow travelers, my wife Mary came down with abdominal pains and bloating. My diagnosis was tropical sprue, a rare disease that is most likely infectious in origin that she picked up in Peru or Brazil.

She (as always) expected me to diagnosis and treat her. But I do not like being Mary’s doctor—it’s too much responsibility. After two months of continued symptoms, I insisted that she see a specialist in intestinal diseases, a gastroenterologist.

I found the most competent specialist in Santa Rosa, California, and after a 15-minute examination by the doctor I was asked to join Mary in his office. The doctor began by agreeing with my diagnosis and suggested a few extra stool and blood tests to rule out other possibilities. After some small talk I agreed, thanked him, and began to leave.

Unfortunately, the doctor had other ideas about the purpose of our visit and began by saying, “You know that colorectal cancer is the third most frequently diagnosed cancer worldwide, with more than 1 million cases and 600,000 deaths every year.”

After a pregnant pause, he continued. “Mrs. McDougall, you are in your fifties, and you need a colonoscopy to prevent colon cancer.” Mary looked puzzled. She had come for help with her abdominal pains and was now being asked to have a procedure for detecting the remote possibility that she might have colon polyps or cancer. She looked to me for a response.

I said, “I understand your concern, but no thanks.” And we began to leave again. In an authoritative tone he insisted, “It would be highly irresponsible not to do this test.” I told him I knew as much about the risk of colon cancer and the supposed benefits of colonoscopy as he did, and the answer is “No.”

The doctor was obviously threatened and loudly declared, “You are risking her life. I am the expert here. I have been doing these procedures for more than 10 years. They are perfectly safe. If you refuse my recommendations I will have to write a note in her records, just in case she dies of colon cancer and you come back and try to sue me.”

As I walked out of his office I said, “I have seen perfectly healthy people killed after having their colon perforated with your six-foot long tubes passed under sedation.”

What bothered me most about this exchange was that I am a doctor, yet he was talking to me in a condescending manner, as if I were a hopelessly ignorant child. I imagine that it must be pure hell for the average patients suffering through his aggressive sales pitch.

As I left I said to the doctor, “You should be ashamed of your behavior and you should probably be reported to your local medical board for showing such disrespect for a patient.”

Colonoscopy screening is unnecessary

Since the early years following the development of colonoscopy in 1969, the procedure has been attacked as being unnecessary and unduly dangerous.

However, with a colonoscopy costing up to $3,000 for each procedure, it has become the gold standard for colon cancer prevention. That prestigious position is now being lost due to recent scientific publications revealing the truth about colonoscopies. Gastroenterologists should expect their incomes to be cut by at least half as the truth becomes more widespread, especially in this climate of out-of-control healthcare spending.

As a young doctor in the 1970s I used a rigid two-foot long sigmoidoscope to check my patients for hemorrhoids, colon polyps, and cancer. The procedure was painful, relatively safe, cost about $100, and could be performed in about 10 minutes without any sedation in my office.

Colonoscopies became popular as a screening tool in the late 1970s. Because this instrument (the colonoscope) must travel through 6 feet of torturous and turning bowel with four right angle turns (rather than only 2 feet with two bends with a sigmoidoscope) much more is involved.

The colonoscopy requires a thorough bowel preparation (lasting as long as three days), sedation, and at least 30 minutes to perform. The risks from the sedation and passage of the tube are considerable. In contrast, nowadays a much more comfortable sigmoidoscope exam (using a flexible instrument) can be performed, which requires at most a day of preparation, costs about $200, and can be completed in 10 minutes.

No sedation is required and harm is rarely caused to the patient. Adequately trained nurse practitioners can perform flexible sigmoidoscopy as competently as gastroenterologists can.

Gastroenterologists who favor colonoscopy over sigmoidoscopy argue that failing to inspect the proximal three to four feet of the colon (which cannot be reached by the sigmoidoscope) is malpractice.

One medical editor in 2000 metaphorically stated, “Relying on flexible sigmoidoscopy is as clinically logical as performing mammography of one breast to screen women for breast cancer.” However, the scientific evidence, even at that time, failed to show any benefit from using colonoscopy over sigmoidoscopy for colorectal cancer prevention.

But because of the self-serving and financial advantages of colonoscopies, sigmoidoscope exams quickly became unfashionable as a screening tool for cancer.

The trend back to the sigmoidoscope

This colonoscopy-dominated trend began to change in January of 2009 when an extensive review of the results of colonoscopy was reported in the Annals of Internal Medicine.

Even though the entire five feet of colon were examined by the colonoscope, prevention of deaths from colorectal cancer were limited to only those polyps removed from the left side of the colon—those last two feet that are easily and safely within the reach of a sigmoidoscope. The findings shook the world of gastrointestinal medicine.

The next big event was the publication of the “Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial,” published in the May 8, 2010 issue of the Lancet.

This study has become the waterloo for the colonoscopy industry. In this massive undertaking, 170,432 individuals 55 to 64 years of age were assigned to either once-only flexible sigmoidoscopy or no screening.

For those who completed the sigmoidoscopy screening the incidence of colorectal cancer was reduced by 33% and mortality by 43%. (Small polyps were removed at the time of the exam.)

Follow-up colonoscopy was reserved for those patients with polyps that met high-risk criteria: 1 cm or larger; three or more adenomas; tubulovillous or villous histology; severe dysplasia or malignancy; or 20 or more hyperplastic polyps above the distal (left side) rectum. Only 5.3% of the participants went on to colonoscopy.

Why are benefits limited to the distal colon?

The reasons that survival benefits are confined to polyps removed from the distal (left) colon are unknown, but there are some suspicions. There are technical reasons in that the proximal (right) side is harder to clean out for visualization and more difficult to pass the scope completely into.

In addition, right and left colon cancers may differ biologically: right-sided cancers are occasionally flat, making them harder to identify and remove. Right-sided colon cancers are also much more aggressive and deadly, and as a result they may less often be found in a precancerous polyp stage, before they have spread (metastasized).

Colonoscopy is an imprecise instrument. Colon cancer arises from polyps (also called adenomas), and these tests miss about 24% of polyps—12% being large polyps (10 mm or greater).

In autopsy studies, approximately 35% of people consuming the typical Western diet are found to have colon polyps.

Two-thirds of colorectal cancers and adenomas are located in the rectum and sigmoid colon, which, as mentioned, can be examined by flexible sigmoidoscopy.

Why is one exam sufficient?

The size of a polyp found on examination is an indicator of how long and how aggressively the polyp has been growing. Large polyps, which are further along this developmental sequence, are more likely to be cancerous.

Polyps less than 5 mm (half inch) are not likely to be cancerous, while 1% of polyps 10 mm (millimeters) in size show cancerous changes, increasing to 17% at 20 mm. Less than 1 in 20 small polyps will grow larger and transform into cancer.

Ninety percent of colorectal cancers occur after the age of 55. Transition time from the earliest changes in the mucous membranes of the colon to the beginning of actual cancer takes on average 10 to 15 years.

Once the cancer begins, the time for metastasis (spreading to other parts of the body), and finally death, takes another 10 to 20 years, Therefore, the whole process from normal cells to cancer and death will span on average 20 to 35 years.

If one flexible sigmoidoscope examination is successfully performed between age 55 and 64, and no polyps are found (or when polyps are found, they are successfully removed) then the risk of dying from left-sided colon cancer has for all practical purposes been eliminated.

In real life, if a polyp destined to become a cancer happened to start the next day after the exam, then the patient would likely die from other causes (a heart attack, stroke, old age) long before the cancer got to him or her. (As discussed above, there is still risk of dying from colon cancer from missed polyps and cancers in the proximal colon.)

Colonoscopy screening is unduly dangerous

In terms of making a decision about whether or not to have a screening performed, the benefits and risks to you must be taken into consideration. The absolute risk of developing colon cancer for people following the Western diet is to 2.5%.

Having one first-degree relative with colon cancer increases the risk to 4.7%, and with two relatives the risk becomes 9.6% (up to the age of 75). This increased risk is in part genetic, but also remember that mother teaches daughter and son how to cook and what to eat.

Harms from a colonoscopy may arise from the preparation, the sedation, and the procedure. In the United States, serious complications occur in an estimated 5 per 1,000 procedures.

When biopsies or polyp removals are performed, then the risk of serious complications, including bleeding, increases. One of the most serious hazards, often leading to death, is perforation of the colon, which occurs in about 1 per 1,000 procedures.

In the face of that disaster consider that to prevent one death from colorectal cancer (the benefit), 1,250 people would need to have a colonoscopy. This is almost an even exchange: for one life saved from cancer, one life is lost (or at least seriously threatened) from a complication, like perforation.

Are Mary and I going to have a flexible sigmoid exam?

The recommendations for performing sigmoidoscopy over colonoscopy exams have become mainstream in medical journals.

An article in the July 28, 2010 issue of the Journal of the American Medical Association concluded, “If de novo decisions were being made today about whether to initiate colonoscopy as a screening tool in place of sigmoidoscopy for average-risk individuals, in light of the available evidence doing so would probably be inappropriate.”

Certainly, this closes the option for either of us getting a colonoscopy done at any age for preventing colon cancer. (Understand that even though the scientific opinions have changed recently, the actual practices among gastroenterologists have not. Plan on being offered a colonoscopy when you see the specialist—that’s what they do)

At ages 63 (John) and 64 (Mary) we certainly do fit into the data that says our risk of dying of colon cancer could be cut nearly in half by having one sigmoidoscopy.

The lifetime risk of dying from colon cancer is about one in 130 for the general population.15 This means that with the test the usual risk would still be less than 1 in 260—long odds for any gambler.

However, those figures are for the general population who have been eating the Western diet (which causes colon cancer) for a lifetime. In countries where people eat rich diets—lots of meat, dairy, fats, sugars, and processed foods—there are high rates of polyps and colon cancer. Conversely, a high intake of starches, fruits, and vegetables is associated with a low risk of colon problems.

It should not be a far reach to believe that what you put into your colon—the partially digested remnants of your food—will determine the health of your colon.

Researchers have uncovered a fifty-fold variation in the incidence of colon cancer worldwide. Our (John and Mary) diet for the past 35 years has been one that favors a lower risk of colon cancer (albeit not a fifty-fold lower risk than seen at the extremes).

Therefore, at the present time our belief is that our risk of colon cancer and polyps is extremely small, and therefore our decision is to not have the test. The small risks and significant inconveniences for us of testing outweigh any potential benefits.

As a practicing physician responsible for people at various risks of colon cancer, however, I do recommend one bowel exam with a flexible sigmoidoscope between ages 55 and 64. I have been making a similar recommendation for the past 17 years since the article “Prevention of colorectal cancer by once-only sigmoidoscopy” appeared in the 1993 issue of the Lancet.

Your doctors had access to this scientific paper too. Even though trends may come and go, honest patient care remains forever.

John A. McDougall, MD, is the founder and medical director of the nationally renowned McDougall Program, a ten-day, residential program located at a luxury resort in Santa Rosa, CA. Dr McDougall has cared for thousands of patients over almost three decades of medical practice and has run a highly successful live-in program for more than 20 years.

Dr McDougall is the author of several national bestsellers including: The McDougall Plan: 12 Days to Dynamic Health, McDougall's Medicine: A Challenging Second Opinion, The McDougall Program for Maximum Weight Loss, The New McDougall Cookbook, The McDougall Program for Women, and his latest ground breaking book, The McDougall Program for a Healthy Heart.

A graduate of Michigan State University's College of Human Medicine, he performed his internship at Queen's Medical Center in Honolulu, Hawaii, and his medical residency at the University of Hawaii. He is certified as an internist by the Board of Internal Medicine and the National Board of Medical Examiners.

To make it easier for people to eat well on the go, Dr McDougall co-founded Dr. McDougall's Right Foods Inc., a producer of high quality vegetarian cuisine. The convenience meals are consistent with his health-supporting guidelines of 10% or less calories from fat, strictly vegetarian so there's no cholesterol, and no added oils.

Visit Dr McDougall’s website for details of how to order his books and DVDs. The full article, with references can also be found here.

The information provided on this site is not a substitute for professional medical advice and care. It is not to be considered medical advice and is not intended to replace consultation with a qualified medical practitioner.

 

Comments   

0 #3 Jackie 2013-11-02 22:10
This sounds soo scary. I am terrified because,I have bad luck anyway and this would end my productive life, if something were to go wrong. I am a VERY busy 68 year old wit a almost full time job, I have Neurofibromatos is..I don.t know if fibroids grow inside of you,but they bleed profusly if nicked on the outside.I have pain in my lower left side(really low) with itching on the skin where the pain is. My Catscan was normal.I do not know what to do. My family doctor suggests a colonoscopy,but I have said NO.
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-1 #2 Isabel 2013-01-02 22:34
I agree that colonoscopy would be performed only in a extreme situations. I got that procedure being 64 years old and on the next day of prep, I threw up it and it was not clear, it was yellow.
After the procedure the doctor said that my colon was very clean, and I had no polyps, etc. everything excellent, but after that I was suffering a hard pain in my rectum, and also stomach ache, specially under my left ribs. Together with all of this, a headache that almost made me feel despair. I went twice to the same physician and he gave me pills that were not working at all, Then I went to the Family practitioner and he prescribed me antibiotics and a purple pills. They worked, but I needed 3 months of purple pills.
Finally the headache and the rectal pain disappeared, but the stomach is still bothering me. It is 1year and 3 months and I am having strange tools, a nervous stomach and acidity I had never had before. Hearth burn and headaches, nausea, irritabhle bowels, and I noticed that I am geiting blisters in my mouth, that almost feels like burning water until I get something to drink. I am taking Prilosec.now anad it is helpingme a lot. Sincerely I do not know what to do, if all of this syntoms are caused because the Colonoscopy or the prep liquid that caused the yelow throw up. I did not have this kind of problems before that colonoscopy..
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0 #1 Clare 2012-01-01 05:41
Here is an extract from a letter sent me by a medical professional I know who works at a surgery centre in the USA:
"I think that it is something that the GI specialists pushed through to make themselves look more important and to make themselves rich.To me it seems as though a colonoscopy is only necessary if you have symptoms or a direct family history of colon cancer. I have always had issues with the prep they give these patients which induces diarrhea. It isn't so bad with a healthy 50 year old but when you give these laxatives to people in their 70s and 80s with other medical problems it becomes really dangerous. Then there's the conveyor belt type treatment of them with doctors doing so many cases back to back. I timed one doctor one evening and he did 9 colonoscopies is 2 1/2 hours. You can't tell me that he's doing the examination properly. On the other hand we have a new young doctor who spends about 45 minutes on each case. If you aren't being thorough there's really no point in doing the exam. Another of our doctors has a financial interest in the lab which investigates the specimens taken during the procedures so his patients have more biopsies done.That's a conflict of interests at the very least. The reason that this is on my mind at present is because of something xxxxx told me about one of our doctors and the way he does his cases. Many of our patients don't take enough of the laxatives, sometimes because they don't understand the instructions or because they make them sick. However, the doctors only get paid for one procedure. If the colon isn't clean they should send the patient home and repeat the procedure in a day or two, when the prep has actually been given, but they don't want to do this because they won't get paid for the second visit. This physician just pushes the scope up and, if he can't see properly because of stool, he just sends the patient home and tells them that there was nothing abnormal on the exam. xxxxx assists with the procedures so he should know.
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